![]() ![]() It is commonly accepted that AKI may have chronic consequences. AKI is independently associated with increased morbidity and mortality as well as increased length of hospital stays Ĭliquez ici pour aller à la section Références]. Cellular pathophysiology of ischemic acute kidney injury J. AKI has been traditionally defined as a rapid (ranging from hours to weeks) decrease in kidney function measured by increases in serum creatinine levels [ 1 Bonventre J.V., Yang L. The duration of ischemia at either body temperature for the organs in situ or at 4 ☌ for grafts will determine the extent of tissue injury ranging from no visible symptoms to acute kidney injury (AKI). For the kidney, IR is either due to cardiac arrest (systemic hypoperfusion), shock, surgical interventions leading to local renal hypoperfusion such as aortic crossclamping, partial nephrectomy as well as transplantation. Ischemia reperfusion (IR) injury occurs when blood supply to part or the whole of an organ is interrupted or drastically reduced. ![]()
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